Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female
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چکیده
Rats Neuroprotective Effects of Female Gonadal Steroids in Reproductively Senescent Female Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.31.1.161 2000;31:161-168 Stroke. http://stroke.ahajournals.org/content/31/1/161 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Neuroprotective effects of female gonadal steroids in reproductively senescent female rats.
BACKGROUND AND PURPOSE Young adult female rats sustain smaller infarcts after experimental stroke than age-matched males. This sex difference in ischemic brain injury in young animals disappears after surgical ovariectomy and can be restored by estrogen replacement. We sought to determine whether ischemic brain injury continues to be smaller in middle-aged, reproductively senescent female rats ...
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Hormone therapy to postmenopausal females increases the risk and severity of ischemic stroke. Our previous work using an animal model of menopause (reproductive senescence) shows that middle cerebral artery occlusion (MCAo) causes a larger cortical-striatal infarct in this older acyclic group compared with younger females. Moreover, although estrogen treatment is neuroprotective in younger fema...
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